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Basic Research

Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell-Derived Hepatocytes for Cell-Based Therapy.
Blackford SJI, Ng SS, Segal JM, King AJF, Austin AL, Kent D, Moore J, Sheldon M, Ilic D, Dhawan A, Mitry RR, Rashid ST. Stem Cells Transl Med. 2019 Feb;8(2):124-137. doi: 10.1002/sctm.18-0084. Epub 2018 Nov 19. [pubmed]

A New High Throughput Screening Platform for Cell Encapsulation in Alginate Hydrogel Shows Improved Hepatocyte Functions by Mesenchymal Stromal Cells Co-encapsulation.
Iansante V, Dhawan A, Masmoudi F, Lee CA, Fernandez-Dacosta R, Walker S, Fitzpatrick E, Mitry RR, Filippi C. Front Med (Lausanne). 2018 Aug 9;5:216. doi: 10.3389/fmed.2018.00216. eCollection 2018. [pubmed]

Cryopreserved neonatal hepatocytes may be a source for transplantation: Evaluation of functionality toward clinical use.
Lee CA, Dhawan A, Iansante V, Lehec S, Khorsandi SE, Filippi C, Walker S, Fernandez-Dacosta R, Heaton N, Bansal S, Mitry RR, Fitzpatrick E.
Liver Transpl. 2018 Mar;24(3):394-406. doi: 10.1002/lt.25015. [pubmed]

Cryopreservation of Hepatocyte Microbeads for Clinical Transplantation.
Jitraruch S, Dhawan A, Hughes RD, Filippi C, Lehec SC, Glover L, Mitry RR.
Cell Transplant. 2017 Jan 20. doi: 10.3727/096368917X694688. [pubmed]

Hypoxic preconditioning potentiates the trophic effects of mesenchymal stem cells on co-cultured human primary hepatocytes.
Qin HH, Filippi C, Sun S, Lehec S, Dhawan A, Hughes RD.
Stem Cell Res Ther. 2015 Dec 1;6:237. doi: 10.1186/s13287-015-0218-7. [pubmed]

Alginate microencapsulated hepatocytes optimised for transplantation in acute liver failure.
Jitraruch S, Dhawan A, Hughes RD, Filippi C, Soong D, Philippeos C, Lehec SC, Heaton ND, Longhi MS, Mitry RR.
PLoS One. 2014 Dec 1;9(12):e113609. doi: 10.1371/journal.pone.0113609. eCollection 2014. [pubmed]

The effect of anterograde persufflation on energy charge and hepatocyte function in donation after cardiac death livers unsuitable for transplant.
Khorsandi SE, Jitraruch S, Fairbanks L, Cotoi C, Jassem W, Vilca-Melendez H, Prachalias A, Dhawan A, Heaton N, Srinivasan P. Liver Transpl. 2014 Mar 7. doi: 10.1002/lt.23864. [Epub ahead of print] [pubmed]

Co-culture with mesenchymal stem cells results in improved viability and function of human hepatocytes.
Fitzpatrick E, Wu Y, Dhadda P, Hughes RD, Mitry RR, Qin H, Lehec SC, Heaton ND, Dhawan A. Cell Transplant. 2013 Oct 18. [Epub ahead of print] [pubmed]

Ex vivo magnetic resonance imaging of transplanted hepatocytes in a rat model of acute liver failure.
Puppi J, Modo M, Dhawan A, Lehec SC, Mitry RR, Hughes RDCell Transplant. 2014;23(3):329-43. doi: 10.3727/096368913X663596. Epub 2013 Feb [pubmed]

Intraportal transplantation of bone derived mesenchymal stem cells in pigs with fulminant hepatic failure.
Jitraruch S, Mitry RR, Dhawan A. Hepatology 2012-10-14 [pubmed]

Use of indocyanine green in functional assessment of  human hepatocytes for  transplantation.
Ho CM, Dhawan A, Hughes RD, Lehec S, Mitry RR. Asian J of Surgery 2012 ;35(1):9-15 [pubmed]

Hepatocyte  labelling with 99mTc-GSA ;a potential non invasive technique for tracking cell transplantation.
Chouhan M, Puppi J, Solanas E, Mitry RR, Dhawan A, Hughes R. Int J Artificial Organ 2012 april. [pubmed]

BMPER protein is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice.
Patel N1, Masaratana P, Diaz-Castro J, Latunde-Dada GO, Qureshi A, Lockyer P, Jacob M, Arno M, Matak P, Mitry RR, Hughes RD, Dhawan A, Patterson C, Simpson RJ, McKie AT. 2012 Feb 3;287(6):4099-106 [pubmed]

Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London.
Puppi J, Strom SC, Hughes RD, Bansal S, Castell JV, Dagher I, Ellis EC, Nowak G, Ericzon BG, Fox IJ, Gómez-Lechón MJ, Guha C, Gupta S, Mitry RR, Ohashi K, Ott M, Reid LM, Roy-Chowdhury J, Sokal E, Weber A, Dhawan A. Cell Transplant. 2012;21(1):1-10. doi: 10.3727/096368911X566208.[pubmed]

The instant blood-mediated inflammatory reaction characterized in hepatocyte transplantation.
Gustafson EK, Elgue G, Hughes RD, Mitry RR, Sanchez J, Haglund U, Meurling S, Dhawan A, Korsgren O, Nilsson B. Transplantation. 2011 Mar 27;91(6):632-8. [pubmed]

Use of a clinically approved iron oxide MRI contrast agent to label human hepatocytes.
Puppi J, Mitry RR, Modo M, Dhawan A, Raja K, Hughes RD. Cell Transplant. 2011;20(6):963-75. doi: 10.3727/096368910X543367. Epub 2010 Nov 19. [pubmed]

N-acetylcysteine improves the viability of human hepatocytes isolated from severely steatotic donor liver tissue.
Sagias FG, Mitry RR, Hughes RD, Lehec SC, Patel AG, Rela M, Mieli-Vergani G, Heaton ND, Dhawan A. Cell Transplant. 2010;19(11):1487-92. [pubmed]

Transferrin receptor 2 is crucial for iron sensing in human hepatocytes.
Rapisarda C, Puppi J, Hughes RD, Dhawan A, Farnaud S, Evans RW, Sharp PA. Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G778-83. doi: 10.1152/ajpgi.00157.2010. Epub 2010 Jun 24. [pubmed]

Bilirubin, a physiological antioxidant, can improve cryopreservation of human hepatocytes.
Galbiati G, Muraca M, Mitry RR, Hughes RD, Lehec SC, Puppi J, Sagias FG, Caruso M, Mieli-Vergani G, Dhawan A. J Pediatr Gastroenterol Nutr. 2010 Jun;50(6):691-3. [pubmed]

Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation.
Terry C, Dhawan A, Mitry RR, Lehec SC, Hughes RD. Liver Transpl. 2010 Feb;16(2):229-37. doi: 10.1002/lt.21983. [pubmed]

Experience of microbiological screening of human hepatocytes for clinical transplantation.
Lehec SC, Hughes RD, Mitry RR, Graver MA, Verma A, Wade JJ, Dhawan A. Cell Transplant. 2009;18(8):941-7. [pubmed]

In vitro effects of sera from children with acute liver failure on metabolic and synthetic activity of cryopreserved human hepatocytes.
Mitry RR, Bansal S, Hughes RD, Mieli-Vergani G, Dhawan A. J Pediatr Gastroenterol Nutr. 2009 May;48(5):604-7. [pubmed]

Clinical Research
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Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure.
Azhar N, Ziraldo C, Barclay D, Rudnick DA, Squires RH, Vodovotz Y; Pediatric Acute Liver Failure Study Group. PLoS One. 2013 Nov 11;8(11):e78202. doi: 10.1371/journal.pone.0078202. eCollection 2013 [pubmed]

Anti-CD20 Monoclonal Antibody Therapy In Functional Bile Salt Export Pump Deficiency After Liver Transplantation.
Grammatikopoulos T, Knisely AS, Dhawan A, Hadzic N, Thompson RJ. J Pediatr Gastroenterol Nutr. 2013 Nov 13. [Epub ahead of print] No abstract available. [pubmed]

Analysis of adipokine concentration in paediatric non-alcoholic fatty liver disease.
Fitzpatrick E, Dew TK, Quaglia A, Sherwood R, Dhawan A. Pediatric Obesity Sep 2012 [pubmed]

Transient elastography is an useful non invasive tool in evaluating fibrosis in paediatric chronic liver disease.
Fitzpatrick E, Quaglia A, Basso M, Vimleshavaran S , Dhawan A. J Pediatr Gastro Nutrition Aug 2012 . [pubmed]

King’s College Hospital criteria for non acetaminophen liver failure in an international cohort of children.
Sundram V, Shneider BL,Dhawan A, Ng V, Belle S, Squires R. J Pediatr Aug 2012. [pubmed]

Predictors of early graft survival after paediatric liver transplantation.
Ciria A, Davilla D,SE Khorsandi, Vilac Melendez H, Dhawan A, Rela M, Heaton N. Liver Transpl Aug 2012 [pubmed]

Intravenous N-acetyl cysteine in pediatric non acetaminophen acute liver failure- a placebo contolled clinical trial.
Squires RH, Dhawan A, Alonso E, Narkewich MR, Shneider BL, Rodrigez N, et al. Hepatology Aug 2012 [pubmed]

Baseline evaluation of serum markers of inflammation and their utility in clinical practice in pediatric liver transplant recipients. Grammaticopolous T, Dhawan A, Bansal S, Wade J, Sherwood R, Verma A. Clinic Res Hepatol Gastroenterol .2012March 20 [pubmed]

Serum protein N-glycosylation in pediatric non-alcholoic fatty liver diaese.
Blomme B, Fitzpatrick E, De Bruyne R, Quaglia A, Dhawan A. Pediatr Obesity. 2012;7(2):165 [pubmed]


Jump to Basic ResearchClinical ResearchReviewsBooks

Human hepatocyte transplantation for liver disease: Current status and future perspectives.
Iansante, V., Mitry, R. R., Filippi, C., Fitzpatrick, E., & Dhawan, A.
Pediatric Research, 2018; 83(1–2).

Instant Blood-Mediated Inflammatory Reaction in Hepatocyte Transplantation: Current Status and Future Perspectives.
Lee CA, Dhawan A, Smith RA, Mitry RR, Fitzpatrick E.
Cell Transplant. 2016;25(7):1227-36. doi: 10.3727/096368916X691286. [pubmed]

Current status of human hepatocyte transplantation and its potential for Wilson’s disease.
Filippi C, Dhawan A.  Ann N Y Acad Sci. 2014 Mar 7. doi: 10.1111/nyas.12386. [Epub ahead of print] [pubmed]

Management of acute rejection in paediatric liver transplantation.
Thangarajah D, O’Meara M, Dhawan A. Paediatr Drugs. 2013 Dec;15(6):459-71. doi: 10.1007/s40272-013-0034-4. Review. [pubmed]

Skin colour: a barrier to early referral of infants with biliary atresia in the UK.
Martin LR, Davenport M, Dhawan A.  Arch Dis Child. 2012 Dec;97(12):1102-3. doi: 10.1136/archdischild-2012-302058. Epub 2012 Oct 18. No abstract available. [pubmed]

Acute liver failure in children and adolescents .
Dhawan A. Clin Res Hepaltol Gastroenterol. 2012 April [pubmed]

Human hepatocyte transplantation: current experience and future challenges.
Dhawan A, Puppi J, Hughes RD, Mitry RR. Nat Rev Gastroenterol Hepatol. 2010 May;7(5):288-98.

Current status of immunosuppression for solid organ transplantation in children. Pediatr Transp .2012;16(2):106-122 [pubmed]
Diagnosis of NAFLD in children and adolescents; position paper of ESPGHAN.
Vajro P, Lenta S, Socha P,Dhawan A, Nobili V. J Ped Gastro Nutr 2012;54(5):700-713 [pubmed]

Current status of hepatocyte transplantation.
Hughes RD, Mitry RR, Dhawan A. Transplantation. 2012, Feb 27. [pubmed]

Book / Chapters
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Introduction to cell culture.
Philippeos C, Hughes RD, Dhawan A and Mitry RR. Methods in Molecular biology . 2011, 112-115. [pubmed]


Hepatocyte Transplantation – Methods and Protocols
Dhawan, Anil; Thangarajah, Dhamyanthi; Hughes, Robin D. (Eds.) Series: Methods in Molecular Biology, Vol. 481; 2009, XVII, 231 p. 51 illus., 15 illus. in color. [Springer link]



Human Cell Culture Protocols
Mitry, Ragai R., Hughes, Robin D. (Eds.)
Series: Methods in Molecular Biology, Vol. 806
3rd ed. 2012, XIV, 435p. 89 illus., 33 illus. in color. [Springer link]



Full list on pubmed

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