role
Head of Quality and Stem Cell Research
Senior Lecturer
qualifications
PhD in Biology, Joseph Fourier University, Grenoble, France, 1999
DEA in Molecular and Cell Biology, Joseph Fourier University, Grenoble, France, 1995
MSc. Physiology and Cell Biology, Joseph Fourier University, Grenoble, France, 1994
BSc. Physiology and Cell Biology, Joseph Fourier University, Grenoble, France, 1993
research project title(s)
Co-encapsulation of hepatocyte and mesenchymal stromal cells for the treatment of acute liver failure
Effect of non-parenchymal cells on the survival and metabolism of hepatocytes
Effect of mesenchymal stroma cells on hepatocyte function and bioenergetics
core expertise
primary hepatocyte biology
hepatocyte metabolism studies
stem cells
bioenergetics/mitochondrial function
GMP development / Quality management
hepatocyte encapsulation for clinical use
reviewing work
EU Horizon 2020 Framework Programme (H2020);
UK BBSRC;
Sweden VINNOVA;
France ANR;
Switzerland HUG;
Scotland CSO.
contact
celine.filippi@kcl.ac.uk
+44 203 299 3137
main publications
Alginate microencapsulated human hepatocytes for the treatment of acute liver failure in children
Anil Dhawan, Nataruks Chaijitraruch, Emer Fitzpatrick, Sanjay Bansal, Celine Filippi, Sharon C Lehec, Nigel D Heaton, Pauline Kane, Anita Verma, Robin D Hughes, Ragai R Mitry. J Hepatol 2020 May;72(5):877-884. doi: 10.1016/j.jhep.2019.12.002. Epub 2019 Dec 13.
Improving engraftment of hepatocyte transplantation using alpha-1 antitrypsin as an immune modulator
Charlotte Lee, Anil Dhawan, Valeria Iansante, Celine Filippi, Ragai Mitry, Joanne Tang, Simon Walker, Raquel Fernandez DaCosta, Siddharth Sinha, Robin D. Hughes, Maria Koulmanda, Emer Fitzpatrick
J Mol Med (Berl) 2019; 97(4): 563–577. Published online 2019 Feb 28. doi: 10.1007/s00109-019-01747-3
A New High Throughput Screening Platform for Cell Encapsulation in Alginate Hydrogel Shows Improved Hepatocyte Functions by Mesenchymal Stromal Cells Co-encapsulation.
Iansante V, Dhawan A, Masmoudi F, Lee CA, Fernandez-Dacosta R, Walker S, Fitzpatrick E, Mitry RR, Filippi C. Front Med (Lausanne). 2018 Aug 9;5:216. doi: 10.3389/fmed.2018.00216. eCollection 2018.
Cryopreserved neonatal hepatocytes may be a source for transplantation: Evaluation of functionality toward clinical use.
Lee CA, Dhawan A, Iansante V, Lehec S, Khorsandi SE, Filippi C, Walker S, Fernandez-Dacosta R, Heaton N, Bansal S, Mitry RR, Fitzpatrick E.
Liver Transpl. 2018 Mar;24(3):394-406. doi: 10.1002/lt.25015.
Cryopreservation of Hepatocyte Microbeads for Clinical Transplantation.
Jitraruch S, Dhawan A, Hughes RD, Filippi C, Lehec SC, Glover L, Mitry RR.
Cell Transplant. 2017 Jan 20. doi: 10.3727/096368917X694688. [pubmed]
Hypoxic preconditioning potentiates the trophic effects of mesenchymal stem cells on co-cultured human primary hepatocytes.
Qin HH, Filippi C, Sun S, Lehec S, Dhawan A, Hughes RD.
Stem Cell Res Ther. 2015 Dec 1;6:237. doi: 10.1186/s13287-015-0218-7.
Alginate microencapsulated hepatocytes optimised for transplantation in acute liver failure.
Jitraruch S, Dhawan A, Hughes RD, Filippi C, Soong D, Philippeos C, Lehec SC, Heaton ND, Longhi MS, Mitry RR.
PLoS One. 2014 Dec 1;9(12):e113609. doi: 10.1371/journal.pone.0113609. eCollection 2014.
A thyroid hormone receptor/KLF9 Axis in human hepatocytes and pluripotent stem cells.
Cvoro A, Devito L, Milton FA, Noli L, Zhang A, Filippi C, Sakai K, Suh JH, Sieglaff DH, Dhawan A, Sakai T, Ilic D, Webb P.
Stem Cells. 2014 Oct 21. doi: 10.1002/stem.1875. [Epub ahead of print]
Current status of human hepatocyte transplantation and its potential for Wilson’s disease.
Filippi C, Dhawan A. Ann N Y Acad Sci. 2014 Mar 7. doi: 10.1111/nyas.12386. [Epub ahead of print]
Toxicology of ZnO and TiO2 nanoparticles on hepatocytes: Impact on metabolism and bioenergetics.
Filippi C, Pryde A, Cowan P, Lee T, Hayes P, Donaldson K, Plevris J, Stone V. Nanotoxicology. 2014 Apr 8. [Epub ahead of print]
Oxidative stress rather than triglyceride accumulation is a determinant of mitochondrial dysfunction in in vitro models of hepatic cellular steatosis.
Lockman KA, Baren JP, Pemberton CJ, Baghdadi H, Burgess KE, Plevris-Papaioannou N, Lee P, Howie F, Beckett G, Pryde A, Jaap AJ, Hayes PC, Filippi C, Plevris JN. Liver Int. 2012 Aug;32(7):1079-92. doi: 10.1111/j.1478-3231.2012.02775.x. Epub 2012 Mar 19.
Development of an invasively monitored porcine model of acetaminophen-induced acute liverfailure.
Newsome PN, Henderson NC, Nelson LJ, Dabos C, Filippi C, Bellamy C, Howie F, Clutton RE, King T, Lee A, Hayes PC, Plevris JN. BMC Gastroenterol. 2010 Mar 30;10:34. doi: 10.1186/1471-230X-10-34.
Hepatic endoderm differentiation from human embryonic stem cells.
Hannoun Z, Filippi C, Sullivan G, Hay DC, Iredale JP. Curr Stem Cell Res Ther. 2010 Sep;5(3):233-44.
Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling.
Hay DC, Fletcher J, Payne C, Terrace JD, Gallagher RC, Snoeys J, Black JR, Wojtacha D, Samuel K, Hannoun Z, Pryde A, Filippi C, Currie IS, Forbes SJ, Ross JA, Newsome PN, Iredale JP. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12301-6. doi: 10.1073/pnas.0806522105.
Improvement of C3A cell metabolism for usage in bioartificial liver support systems.
Filippi C, Keatch SA, Rangar D, Nelson LJ, Hayes PC, Plevris JN. J Hepatol. 2004 Oct;41(4):599-605.
[PubMed list – main publications]
dhawan lab 